CBD AND ANXIETY
Effects of short-term cannabidiol treatment on
response to social stress in subjects at clinical high risk of
developing psychosis.
Appiah-Kusi E, Petros N, Wilson R, Colizzi M, Bossong MG, Valmaggia
L, Mondelli V, McGuire P, Bhattacharyya S.
Psychopharmacology (Berl). 2020 Jan 8. doi:
10.1007/s00213-019-05442-6. [Epub ahead of print] PMID:31915861
Effects of acute cannabidiol administration on
anxiety and tremors induced by a Simulated Public Speaking Test in
patients with Parkinson's disease.
de Faria SM, de Morais Fabrício D, Tumas V, Castro PC, Ponti MA,
Hallak JE, Zuardi AW, Crippa JAS, Chagas MHN.
J Psychopharmacol. 2020 Jan 7:269881119895536. doi:
10.1177/0269881119895536. [Epub ahead of print] PMID:31909680
Use of cannabidiol in anxiety and anxiety-related
disorders.
Skelley JW, Deas CM, Curren Z, Ennis J.
J Am Pharm Assoc (2003). 2019 Dec 19. pii: S1544-3191(19)30514-X.
doi: 10.1016/j.japh.2019.11.008. [Epub ahead of print] Review.
PMID:31866386
Anxiolytic Effects of Repeated Cannabidiol
Treatment in Teenagers With Social Anxiety Disorders.
Masataka N.
Front Psychol. 2019 Nov 8;10:2466. doi: 10.3389/fpsyg.2019.02466.
eCollection 2019. PMID:31787910
Free PMC Article
Cannabinoids for the treatment of mental disorders
and symptoms of mental disorders: a systematic review and
meta-analysis.
Black N, Stockings E, Campbell G, Tran LT, Zagic D, Hall WD, Farrell
M, Degenhardt L.
Lancet Psychiatry. 2019 Dec;6(12):995-1010. doi:
10.1016/S2215-0366(19)30401-8. Epub 2019 Oct 28. Erratum in: Lancet Psychiatry. 2020 Jan;7(1):e3.
PMID:31672337
Effects of cannabidiol (CBD) in neuropsychiatric
disorders: A review of pre-clinical and clinical findings.
Elsaid S, Kloiber S, Le Foll B.
Prog Mol Biol Transl Sci. 2019;167:25-75. doi:
10.1016/bs.pmbts.2019.06.005. Epub 2019 Aug 28. PMID:31601406
Cannabinoids and Mental Health, Part 2: The Search
for Clinical Applications.
Penn A.
J Psychosoc Nurs Ment Health Serv. 2019 Oct 1;57(10):7-11. doi:
10.3928/02793695-20190919-02. PMID:31573659
Preclinical and Clinical Evidence Supporting Use
of Cannabidiol in Psychiatry.
Calapai G, Mannucci C, Chinou I, Cardia L, Calapai F, Sorbara EE,
Firenzuoli B, Ricca V, Gensini GF, Firenzuoli F.
Evid Based Complement Alternat Med. 2019 Aug 29;2019:2509129. doi:
10.1155/2019/2509129. eCollection 2019. Review. PMID:31558911
Free PMC Article
Use of Medicinal Cannabis and Synthetic
Cannabinoids in Post-Traumatic Stress Disorder (PTSD): A
Systematic Review.
Orsolini L, Chiappini S, Volpe U, Berardis D, Latini R, Papanti GD,
Corkery AJM.
Medicina (Kaunas). 2019 Aug 23;55(9). pii: E525. doi:
10.3390/medicina55090525. Review. PMID:31450833
Free PMC Article
Cannabidiol (CBD) reduces anxiety-related behavior
in mice via an FMRP-independent mechanism.
Zieba J, Sinclair D, Sebree T, Bonn-Miller M, Gutterman D, Siegel S,
Karl T.
Pharmacol Biochem Behav. 2019 Jun;181:93-100. doi:
10.1016/j.pbb.2019.05.002. Epub 2019 May 4. PMID:31063743
Cannabidiol: Recent advances and new insights for
neuropsychiatric disorders treatment.
Premoli M, Aria F, Bonini SA, Maccarinelli G, Gianoncelli A, Pina
SD, Tambaro S, Memo M, Mastinu A.
Life Sci. 2019 May 1;224:120-127. doi: 10.1016/j.lfs.2019.03.053.
Epub 2019 Mar 22. Review. PMID:30910646
Cannabidiol enhancement of exposure therapy in
treatment refractory patients with phobias: study protocol of a
randomized controlled trial.
van der Flier FE, Kwee CMB, Cath DC, Batelaan NM, Groenink L, Duits
P, van der Veen DC, van Balkom AJLM, Baas JMP.
BMC Psychiatry. 2019 Feb 13;19(1):69. doi:
10.1186/s12888-019-2022-x. PMID:30760241
Free PMC Article
Cannabidiol in Anxiety and Sleep: A Large Case
Series.
Shannon S, Lewis N, Lee H, Hughes S.
Perm J. 2019;23:18-041. doi: 10.7812/TPP/18-041. PMID:30624194
Free PMC Article
Δ-9-Tetrahydrocannabinol and Cannabidiol produce
dissociable effects on prefrontal cortical executive function and
regulation of affective behaviors.
Szkudlarek HJ, Desai SJ, Renard J, Pereira B, Norris C, Jobson CEL,
Rajakumar N, Allman BL, Laviolette SR.
Neuropsychopharmacology. 2019 Mar;44(4):817-825. doi:
10.1038/s41386-018-0282-7. Epub 2018 Nov 27. PMID:30538288
Cannabidiol presents an inverted U-shaped
dose-response curve in a simulated public speaking test.
Linares IM, Zuardi AW, Pereira LC, Queiroz RH, Mechoulam R,
Guimarães FS, Crippa JA.
Braz J Psychiatry. 2019 Jan-Feb;41(1):9-14. doi:
10.1590/1516-4446-2017-0015. Epub 2018 Oct 11. PMID:30328956
Free PMC Article
Antiapoptotic effects of cannabidiol in an
experimental model of cognitive decline induced by brain iron
overload.
da Silva VK, de Freitas BS, Garcia RCL, Monteiro RT, Hallak JE,
Zuardi AW, Crippa JAS, Schröder N.
Transl Psychiatry. 2018 Sep 3;8(1):176. doi:
10.1038/s41398-018-0232-5. PMID:30177808
Free PMC Article
Cannabidiol modulates serotonergic transmission
and reverses both allodynia and anxiety-like behavior in a model
of neuropathic pain.
De Gregorio D, McLaughlin RJ, Posa L, Ochoa-Sanchez R, Enns J,
Lopez-Canul M, Aboud M, Maione S, Comai S, Gobbi G.
Pain. 2019 Jan;160(1):136-150. doi: 10.1097/j.pain.0000000000001386.
PMID:30157131
Free PMC Article
Dual diagnosis of obsessive compulsive and
compulsive buying disorders: Demographic, clinical, and
psychiatric correlates.
Kim HS, Hodgins DC, Torres AR, Fontenelle LF, do Rosário MC, de
Mathis MA, Ferrão YA, Miguel EC, Tavares H.
Compr Psychiatry. 2018 Oct;86:67-73. doi:
10.1016/j.comppsych.2018.07.013. Epub 2018 Jul 29. PMID:30081209
Pharmacological properties of cannabidiol in the
treatment of psychiatric disorders: a critical overview.
Mandolini GM, Lazzaretti M, Pigoni A, Oldani L, Delvecchio G,
Brambilla P.
Epidemiol Psychiatr Sci. 2018 Aug;27(4):327-335. doi:
10.1017/S2045796018000239. Epub 2018 May 23. Review. PMID:29789034
Review of the neurological benefits of
phytocannabinoids.
Maroon J, Bost J.
Surg Neurol Int. 2018 Apr 26;9:91. doi: 10.4103/sni.sni_45_18.
eCollection 2018. Review. PMID:29770251
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Learning and memory is modulated by cannabidiol
when administered during trace fear-conditioning.
Uhernik AL, Montoya ZT, Balkissoon CD, Smith JP.
Neurobiol Learn Mem. 2018 Mar;149:68-76. doi:
10.1016/j.nlm.2018.02.009. Epub 2018 Feb 9. PMID:29432803
Clinical and Preclinical Evidence for Functional
Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol.
Boggs DL, Nguyen JD, Morgenson D, Taffe MA, Ranganathan M.
Neuropsychopharmacology. 2018 Jan;43(1):142-154. doi:
10.1038/npp.2017.209. Epub 2017 Sep 6. Review. PMID:28875990
Free PMC Article
Cannabidiol Does Not Dampen Responses to Emotional
Stimuli in Healthy Adults.
Arndt DL, de Wit H.
Cannabis Cannabinoid Res. 2017 Jun 1;2(1):105-113. doi:
10.1089/can.2017.0014. eCollection 2017. PMID:28861510
Free PMC Article
Cannabidiol in medical marijuana: Research vistas
and potential opportunities.
Rong C, Lee Y, Carmona NE, Cha DS, Ragguett RM, Rosenblat JD, Mansur
RB, Ho RC, McIntyre RS.
Pharmacol Res. 2017 Jul;121:213-218. doi:
10.1016/j.phrs.2017.05.005. Epub 2017 May 10. Review. PMID:28501518
Effect of prior foot shock stress and Δ9-tetrahydrocannabinol,
cannabidiolic acid, and cannabidiol on anxiety-like responding in
the light-dark emergence test in rats.
Rock EM, Limebeer CL, Petrie GN, Williams LA, Mechoulam R, Parker
LA.
Psychopharmacology (Berl). 2017 Jul;234(14):2207-2217. doi:
10.1007/s00213-017-4626-5. Epub 2017 Apr 20. PMID:28424834
Could cannabidiol be used as an alternative to
antipsychotics?
Fakhoury M.
J Psychiatr Res. 2016 Sep;80:14-21. doi:
10.1016/j.jpsychires.2016.05.013. Epub 2016 May 28. Review.
PMID:27267317
Evidences for the Anti-panic Actions of
Cannabidiol.
Soares VP, Campos AC.
Curr Neuropharmacol. 2017;15(2):291-299. Review. PMID:27157263
Free PMC Article
Prohedonic Effect of Cannabidiol in a Rat Model of
Depression.
Shoval G, Shbiro L, Hershkovitz L, Hazut N, Zalsman G, Mechoulam R,
Weller A.
Neuropsychobiology. 2016;73(2):123-9. doi: 10.1159/000443890. Epub
2016 Mar 25. PMID:27010632
Cannabidiol, neuroprotection and neuropsychiatric
disorders.
Campos AC, Fogaça MV, Sonego AB, Guimarães FS.
Pharmacol Res. 2016 Oct;112:119-127. doi:
10.1016/j.phrs.2016.01.033. Epub 2016 Feb 1. Review. PMID:26845349
Neural correlates of interactions between
cannabidiol and Δ(9) -tetrahydrocannabinol in mice: implications
for medical cannabis.
Todd SM, Arnold JC.
Br J Pharmacol. 2016 Jan;173(1):53-65. doi: 10.1111/bph.13333. Epub
2015 Nov 18. PMID:26377899
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Cannabidiol as a Potential Treatment for Anxiety
Disorders.
Blessing EM, Steenkamp MM, Manzanares J, Marmar CR.
Neurotherapeutics. 2015 Oct;12(4):825-36. doi:
10.1007/s13311-015-0387-1. Review. PMID:26341731
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Influence of single and repeated cannabidiol
administration on emotional behavior and markers of cell
proliferation and neurogenesis in non-stressed mice.
Schiavon AP, Bonato JM, Milani H, Guimarães FS, Weffort de Oliveira
RM.
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 4;64:27-34. doi:
10.1016/j.pnpbp.2015.06.017. Epub 2015 Jul 14. PMID:26187374
Δ9-Tetrahydrocannabinol alone and combined with
cannabidiol mitigate fear memory through reconsolidation
disruption.
Stern CA, Gazarini L, Vanvossen AC, Zuardi AW, Galve-Roperh I,
Guimaraes FS, Takahashi RN, Bertoglio LJ.
Eur Neuropsychopharmacol. 2015 Jun;25(6):958-65. doi:
10.1016/j.euroneuro.2015.02.001. Epub 2015 Feb 16. PMID:25799920
Effects of intra-infralimbic prefrontal cortex
injections of cannabidiol in the modulation of emotional behaviors
in rats: contribution of 5HT₁A receptors and stressful
experiences.
Marinho AL, Vila-Verde C, Fogaça MV, Guimarães FS.
Behav Brain Res. 2015 Jun 1;286:49-56. doi:
10.1016/j.bbr.2015.02.023. Epub 2015 Feb 19. PMID:25701682
Cannabidiol increases survival and promotes rescue
of cognitive function in a murine model of cerebral malaria.
Campos AC, Brant F, Miranda AS, Machado FS, Teixeira AL.
Neuroscience. 2015 Mar 19;289:166-80. doi:
10.1016/j.neuroscience.2014.12.051. Epub 2015 Jan 13. PMID:25595981
Antidepressant-like and anxiolytic-like effects of
cannabidiol: a chemical compound of Cannabis sativa.
de Mello Schier AR, de Oliveira Ribeiro NP, Coutinho DS, Machado S,
Arias-Carrión O, Crippa JA, Zuardi AW, Nardi AE, Silva AC.
CNS Neurol Disord Drug Targets. 2014;13(6):953-60. Review.
PMID:24923339
Effects of intra-prelimbic prefrontal cortex
injection of cannabidiol on anxiety-like behavior: involvement of
5HT1A receptors and previous stressful experience.
Fogaça MV, Reis FM, Campos AC, Guimarães FS.
Eur Neuropsychopharmacol. 2014 Mar;24(3):410-9. doi:
10.1016/j.euroneuro.2013.10.012. Epub 2013 Oct 31. PMID:24321837
Cannabidiol reverses the mCPP-induced increase in
marble-burying behavior.
Nardo M, Casarotto PC, Gomes FV, Guimarães FS.
Fundam Clin Pharmacol. 2014 Oct;28(5):544-50. doi:
10.1111/fcp.12051. Epub 2013 Oct 25. PMID:24118015
The anxiolytic effect of cannabidiol on
chronically stressed mice depends on hippocampal neurogenesis:
involvement of the endocannabinoid system.
Campos AC, Ortega Z, Palazuelos J, Fogaça MV, Aguiar DC,
Díaz-Alonso J, Ortega-Gutiérrez S, Vázquez-Villa H, Moreira FA,
Guzmán M, Galve-Roperh I, Guimarães FS.
Int J Neuropsychopharmacol. 2013 Jul;16(6):1407-19. doi:
10.1017/S1461145712001502. Epub 2013 Jan 9. PMID:23298518
Cannabidiol blocks long-lasting behavioral
consequences of predator threat stress: possible involvement of
5HT1A receptors.
Campos AC, Ferreira FR, Guimarães FS.
J Psychiatr Res. 2012 Nov;46(11):1501-10. doi:
10.1016/j.jpsychires.2012.08.012. Epub 2012 Sep 11. PMID:22979992
Cannabidiol, a Cannabis sativa constituent, as an
anxiolytic drug.
Schier AR, Ribeiro NP, Silva AC, Hallak JE, Crippa JA, Nardi AE,
Zuardi AW.
Braz J Psychiatry. 2012 Jun;34 Suppl 1:S104-10. Review. English,
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Distinct neurobehavioural effects of cannabidiol
in transmembrane domain neuregulin 1 mutant mice.
Long LE, Chesworth R, Huang XF, Wong A, Spiro A, McGregor IS, Arnold
JC, Karl T.
PLoS One. 2012;7(4):e34129. doi: 10.1371/journal.pone.0034129. Epub
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Endocannabinoid system dysfunction in mood and
related disorders.
Ashton CH, Moore PB.
Acta Psychiatr Scand. 2011 Oct;124(4):250-61. doi:
10.1111/j.1600-0447.2011.01687.x. Epub 2011 Mar 9. Review.
PMID:21916860
Effect of cannabidiol on sleep disruption induced
by the repeated combination tests consisting of open field and
elevated plus-maze in rats.
Hsiao YT, Yi PL, Li CL, Chang FC.
Neuropharmacology. 2012 Jan;62(1):373-84. doi:
10.1016/j.neuropharm.2011.08.013. Epub 2011 Aug 16. PMID:21867717
Plasma and brain pharmacokinetic profile of
cannabidiol (CBD), cannabidivarine (CBDV),
Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats
and mice following oral and intraperitoneal administration and CBD
action on obsessive-compulsive behaviour.
Deiana S, Watanabe A, Yamasaki Y, Amada N, Arthur M, Fleming S,
Woodcock H, Dorward P, Pigliacampo B, Close S, Platt B, Riedel G.
Psychopharmacology (Berl). 2012 Feb;219(3):859-73. doi:
10.1007/s00213-011-2415-0. Epub 2011 Jul 28. PMID:21796370
Cannabidiol reduces the anxiety induced by
simulated public speaking in treatment-naïve social phobia
patients.
Bergamaschi MM, Queiroz RH, Chagas MH, de Oliveira DC, De Martinis
BS, Kapczinski F, Quevedo J, Roesler R, Schröder N, Nardi AE,
Martín-Santos R, Hallak JE, Zuardi AW, Crippa JA.
Neuropsychopharmacology. 2011 May;36(6):1219-26. doi:
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Neural basis of anxiolytic effects of cannabidiol
(CBD) in generalized social anxiety disorder: a preliminary
report.
Crippa JA, Derenusson GN, Ferrari TB, Wichert-Ana L, Duran FL,
Martin-Santos R, Simões MV, Bhattacharyya S, Fusar-Poli P, Atakan
Z, Santos Filho A, Freitas-Ferrari MC, McGuire PK, Zuardi AW,
Busatto GF, Hallak JE.
J Psychopharmacol. 2011 Jan;25(1):121-30. doi:
10.1177/0269881110379283. Epub 2010 Sep 9. PMID:20829306
A behavioural comparison of acute and chronic
Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice.
Long LE, Chesworth R, Huang XF, McGregor IS, Arnold JC, Karl T.
Int J Neuropsychopharmacol. 2010 Aug;13(7):861-76. doi:
10.1017/S1461145709990605. Epub 2009 Sep 29. PMID:19785914
Modulation of effective connectivity during
emotional processing by Delta 9-tetrahydrocannabinol and
cannabidiol.
Fusar-Poli P, Allen P, Bhattacharyya S, Crippa JA, Mechelli A,
Borgwardt S, Martin-Santos R, Seal ML, O'Carrol C, Atakan Z, Zuardi
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Int J Neuropsychopharmacol. 2010 May;13(4):421-32. doi:
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Evidence for a potential role for TRPV1 receptors
in the dorsolateral periaqueductal gray in the attenuation of the
anxiolytic effects of cannabinoids.
Campos AC, Guimarães FS.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov
13;33(8):1517-21. doi: 10.1016/j.pnpbp.2009.08.017. Epub 2009 Sep 6.
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Cannabidiol reverses the reduction in social
interaction produced by low dose Delta(9)-tetrahydrocannabinol in
rats.
Malone DT, Jongejan D, Taylor DA.
Pharmacol Biochem Behav. 2009 Aug;93(2):91-6. doi:
10.1016/j.pbb.2009.04.010. Epub 2009 Apr 23. PMID:19393686
Distinct effects of {delta}9-tetrahydrocannabinol
and cannabidiol on neural activation during emotional processing.
Fusar-Poli P, Crippa JA, Bhattacharyya S, Borgwardt SJ, Allen P,
Martin-Santos R, Seal M, Surguladze SA, O'Carrol C, Atakan Z, Zuardi
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Arch Gen Psychiatry. 2009 Jan;66(1):95-105. doi:
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[Treatment of compulsive buying].
Mueller A, de Zwaan M.
Fortschr Neurol Psychiatr. 2008 Aug;76(8):478-83. doi:
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Neural basis of Delta-9-tetrahydrocannabinol and
cannabidiol: effects during response inhibition.
Borgwardt SJ, Allen P, Bhattacharyya S, Fusar-Poli P, Crippa JA,
Seal ML, Fraccaro V, Atakan Z, Martin-Santos R, O'Carroll C, Rubia
K, McGuire PK.
Biol Psychiatry. 2008 Dec 1;64(11):966-73. doi:
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Cannabidiol, a Cannabis sativa constituent, as an
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Zuardi AW, Crippa JA, Hallak JE, Moreira FA, Guimarães FS.
Braz J Med Biol Res. 2006 Apr;39(4):421-9. Epub 2006 Apr 3. Review.
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Antianxiety effect of cannabidiol in the elevated
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Guimarães FS, Chiaretti TM, Graeff FG, Zuardi AW.
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Action of cannabidiol on the anxiety and other
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Zuardi AW, Shirakawa I, Finkelfarb E, Karniol IG.
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