CBD AND DIABETES
Cannabidiol improves metabolic dysfunction in
middle-aged diabetic rats submitted to a chronic cerebral
hypoperfusion.
Zorzenon MRT, Santiago AN, Mori MA, Piovan S, Jansen CA, Perina
Padilha ME, Ciotta SR, Cezar de Freitas Mathias P, Guimarães FS,
Weffort de Oliveira RM, Milani PG, Mareze-Costa CE.
Chem Biol Interact. 2019 Oct 1;312:108819. doi:
10.1016/j.cbi.2019.108819. Epub 2019 Sep 6. PMID:31499052
A systematic review of cannabidiol dosing in
clinical populations.
Millar SA, Stone NL, Bellman ZD, Yates AS, England TJ, O'Sullivan
SE.
Br J Clin Pharmacol. 2019 Sep;85(9):1888-1900. doi:
10.1111/bcp.14038. Epub 2019 Jul 19. Review. PMID:31222854
Free PMC Article
Analog Derivatization of Cannabidiol for Improved
Ocular Permeation.
Taskar P, Adelli G, Patil A, Lakhani P, Ashour E, Gul W, ElSohly M,
Majumdar S.
J Ocul Pharmacol Ther. 2019 Jun;35(5):301-310. doi:
10.1089/jop.2018.0141. Epub 2019 Apr 18.
PMID:30998110
Cannabidiol attenuates mechanical allodynia in
streptozotocin-induced diabetic rats via serotonergic system
activation through 5-HT1A receptors.
Jesus CHA, Redivo DDB, Gasparin AT, Sotomaior BB, de Carvalho
MC, Genaro K, Zuardi AW, Hallak JEC, Crippa JA, Zanoveli JM, da
Cunha JM.
Brain Res. 2019 Jul 15;1715:156-164. doi:
10.1016/j.brainres.2019.03.014. Epub 2019 Mar 18.
PMID:30898678
Effects of Cannabidiol on Diabetes Outcomes and
Chronic Cerebral Hypoperfusion Comorbidities in Middle-Aged Rats.
Santiago AN, Mori MA, Guimarães FS, Milani H, Weffort de Oliveira
RM.
Neurotox Res. 2019 Feb;35(2):463-474. doi:
10.1007/s12640-018-9972-5. Epub 2018 Nov 14.
PMID:30430393
Is Cannabidiol a Promising Substance for New Drug
Development? A Review of its Potential Therapeutic Applications.
Noreen N, Muhammad F, Akhtar B, Azam F, Anwar MI.
Crit Rev Eukaryot Gene Expr. 2018;28(1):73-86. doi:
10.1615/CritRevEukaryotGeneExpr.2018021528. Review.
PMID:29773016
Inhibition of aldose reductase activity by
Cannabis sativa chemotypes extracts with high content of
cannabidiol or cannabigerol.
Smeriglio A, Giofrè SV, Galati EM, Monforte MT, Cicero N, D'Angelo
V, Grassi G, Circosta C.
Fitoterapia. 2018 Jun;127:101-108. doi:
10.1016/j.fitote.2018.02.002. Epub 2018 Feb 7.
PMID:29427593
Abnormal cannabidiol confers cardioprotection in
diabetic rats independent of glycemic control.
Matouk AI, Taye A, El-Moselhy MA, Heeba GH, Abdel-Rahman AA.
Eur J Pharmacol. 2018 Feb 5;820:256-264. doi:
10.1016/j.ejphar.2017.12.039. Epub 2017 Dec 20.
PMID:29274332
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In Vivo Cannabidiol Treatment Improves
Endothelium-Dependent Vasorelaxation in Mesenteric Arteries of
Zucker Diabetic Fatty Rats.
Wheal AJ, Jadoon K, Randall MD, O'Sullivan SE.
Front Pharmacol. 2017 May 18;8:248. doi: 10.3389/fphar.2017.00248.
eCollection 2017.
PMID:28572770
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Experimental cannabidiol treatment
reduces early pancreatic inflammation in type 1
diabetes.
Lehmann C, Fisher NB, Tugwell B, Szczesniak A, Kelly M, Zhou J.
Clin Hemorheol Microcirc. 2016;64(4):655-662. doi:
10.3233/CH-168021.
PMID:27767974
Efficacy and Safety of Cannabidiol and
Tetrahydrocannabivarin on Glycemic and Lipid Parameters in
Patients With Type 2 Diabetes: A Randomized, Double-Blind,
Placebo-Controlled, Parallel Group Pilot Study.
Jadoon KA, Ratcliffe SH, Barrett DA, Thomas EL, Stott C, Bell JD,
O'Sullivan SE, Tan GD.
Diabetes Care. 2016 Oct;39(10):1777-86. doi: 10.2337/dc16-0650. Epub
2016 Aug 29.
PMID:27573936
Cannabidiol improves vasorelaxation in Zucker
diabetic fatty rats through cyclooxygenase activation.
Wheal AJ, Cipriano M, Fowler CJ, Randall MD, O'Sullivan SE.
J Pharmacol Exp Ther. 2014 Nov;351(2):457-66. doi:
10.1124/jpet.114.217125. Epub 2014 Sep 11.
PMID:25212218
Cannabidiol attenuates cardiac dysfunction,
oxidative stress, fibrosis, and inflammatory and cell death
signaling pathways in diabetic cardiomyopathy.
Rajesh M, Mukhopadhyay P, Bátkai S, Patel V, Saito K, Matsumoto S,
Kashiwaya Y, Horváth B, Mukhopadhyay B, Becker L, Haskó G, Liaudet
L, Wink DA, Veves A, Mechoulam R, Pacher P.
J Am Coll Cardiol. 2010 Dec 14;56(25):2115-25. doi:
10.1016/j.jacc.2010.07.033.
PMID:21144973
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Mediation of cannabidiol anti-inflammation in the
retina by equilibrative nucleoside transporter and A2A adenosine
receptor.
Liou GI, Auchampach JA, Hillard CJ, Zhu G, Yousufzai B, Mian S, Khan
S, Khalifa Y.
Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5526-31. doi:
10.1167/iovs.08-2196. Epub 2008 Jul 18. PMID:18641283
Free PMC Article
Cannabidiol arrests onset of autoimmune diabetes
in NOD mice.
Weiss L, Zeira M, Reich S, Slavin S, Raz I, Mechoulam R, Gallily R.
Neuropharmacology. 2008 Jan;54(1):244-9. Epub 2007 Jul 17.
PMID:17714746
Free PMC Article
Cannabidiol attenuates high glucose-induced
endothelial cell inflammatory response and barrier disruption.
Rajesh M, Mukhopadhyay P, Bátkai S, Haskó G, Liaudet L, Drel VR,
Obrosova IG, Pacher P.
Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H610-9. Epub 2007
Mar 23.
PMID:17384130
Free PMC Article
Cannabidiol lowers incidence of diabetes in
non-obese diabetic mice.
Weiss L, Zeira M, Reich S, Har-Noy M, Mechoulam R, Slavin S, Gallily
R.
Autoimmunity. 2006 Mar;39(2):143-51.
PMID:16698671
Anticoagulant effects of a Cannabis extract in an
obese rat model.
Coetzee C, Levendal RA, van de Venter M, Frost CL.
Phytomedicine. 2007 May;14(5):333-7. Epub 2006 Apr 27.
PMID:16644197
Neuroprotective and blood-retinal
barrier-preserving effects of cannabidiol in experimental
diabetes.
El-Remessy AB, Al-Shabrawey M, Khalifa Y, Tsai NT, Caldwell RB, Liou
GI.
Am J Pathol. 2006 Jan;168(1):235-44.
PMID:16400026
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