CBD AND INFLAMMATION
Antioxidative and Anti-Inflammatory Properties of
Cannabidiol.
Atalay S, Jarocka-Karpowicz I, Skrzydlewska E.
Antioxidants (Basel). 2019 Dec 25;9(1). pii: E21. doi:
10.3390/antiox9010021. Review.
PMID:31881765
Free Article
Structure-Effect Relationships of Novel
Semi-Synthetic Cannabinoid Derivatives.
Götz MR, Collado JA, Fernández-Ruiz J, Fiebich BL, García-Toscano
L, Gómez-Cañas M, Koch O, Leha A, Muñoz E, Navarrete C, Pazos MR,
Holzgrabe U.
Front Pharmacol. 2019 Nov 20;10:1284. doi: 10.3389/fphar.2019.01284.
eCollection 2019.
PMID:31824305
Free PMC Article
Effects of O-1602 and CBD on TNBS-induced colonic
disturbances.
Wei D, Wang H, Yang J, Dai Z, Yang R, Meng S, Li Y, Lin X.
Neurogastroenterol Motil. 2019 Dec 4:e13756. doi: 10.1111/nmo.13756.
[Epub ahead of print]
PMID:31802588
Long-term benefit from immune modulation and
anti-inflammatory treatment in metastatic mesothelioma.
Dalgleish AG, McLean E, Patel N, Rahman N.
Respir Med Case Rep. 2019 Nov 21;29:100971. doi:
10.1016/j.rmcr.2019.100971. eCollection 2020.
PMID:31788420
Free PMC Article Cannabinoids and inflammation: implications for
people living with HIV.
Costiniuk CT, Jenabian MA.
AIDS. 2019 Dec 1;33(15):2273-2288. doi:
10.1097/QAD.0000000000002345.
PMID:31764093
Cannabis Influences the Putative Cytokines-Related
Pathway of Epilepsy among Egyptian Epileptic Patients.
M Taalab Y, Mohammed WF, Helmy MA, Othman AAA, Darwish M, Hassan I,
Abbas M.
Brain Sci. 2019 Nov 20;9(12). pii: E332. doi:
10.3390/brainsci9120332.
PMID:31757102
Free PMC Article Cannabidiol Regulates Gene Expression in
Encephalitogenic T cells Using Histone Methylation and noncoding
RNA during Experimental Autoimmune Encephalomyelitis. Yang X,
Bam M, Nagarkatti PS, Nagarkatti M.
Sci Rep. 2019 Oct 31;9(1):15780. doi: 10.1038/s41598-019-52362-8.
PMID:31673072
Free PMC Article Cannabidiol prevents LPS-induced microglial
inflammation by inhibiting ROS/NF-κB-dependent signaling and
glucose consumption.
Dos-Santos-Pereira M, Guimarães FS, Del-Bel E, Raisman-Vozari R,
Michel PP.
Glia. 2020 Mar;68(3):561-573. doi: 10.1002/glia.23738. Epub 2019 Oct
24.
PMID:31647138
Cannabidiol and Cannabinoid Compounds as Potential
Strategies for Treating Parkinson's Disease and L-DOPA-Induced
Dyskinesia.
Junior NCF, Dos-Santos-Pereira M, Guimarães FS, Del Bel E.
Neurotox Res. 2020 Jan;37(1):12-29. doi: 10.1007/s12640-019-00109-8.
Epub 2019 Oct 22. Review.
PMID:31637586
Effects of cannabidiol (CBD) in neuropsychiatric
disorders: A review of pre-clinical and clinical findings.
Elsaid S, Kloiber S, Le Foll B.
Prog Mol Biol Transl Sci. 2019;167:25-75. doi:
10.1016/bs.pmbts.2019.06.005. Epub 2019 Aug 28.
PMID:31601406
Beyond THC and Endocannabinoids.
Pacher P, Kogan NM, Mechoulam R.
Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:637-659. doi:
10.1146/annurev-pharmtox-010818-021441. Epub 2019 Oct 3.
PMID:31580774
Medical cannabis for inflammatory bowel disease:
real-life experience of mode of consumption and assessment of
side-effects. Naftali T, Bar-Lev Schleider L, Sklerovsky
Benjaminov F, Lish I, Konikoff FM, Ringel Y.
Eur J Gastroenterol Hepatol. 2019 Nov;31(11):1376-1381. doi:
10.1097/MEG.0000000000001565.
PMID:31567639
Synthetic Strategies for (-)-Cannabidiol and Its
Structural Analogs.
Jung B, Lee JK, Kim J, Kang EK, Han SY, Lee HY, Choi IS.
Chem Asian J. 2019 Nov 4;14(21):3749-3762. doi:
10.1002/asia.201901179. Epub 2019 Oct 8. Review.
PMID:31529613
Cannabinoids Δ9-tetrahydrocannabinol
and cannabidiol may be effective against methamphetamine induced
mitochondrial dysfunction and inflammation by modulation of
Toll-like type-4(Toll-like 4) receptors and NF-κB signaling.
Majdi F, Taheri F, Salehi P, Motaghinejad M, Safari S.
Med Hypotheses. 2019 Dec;133:109371. doi:
10.1016/j.mehy.2019.109371. Epub 2019 Aug 19.
PMID:31465975
Cannabinoids and inflammation: Implications for
People Living with HIV.
Costiniuk CT, Jenabian MA.
AIDS. 2019 Aug 12. doi: 10.1097/QAD.0000000000002345. [Epub ahead of
print]
PMID:31408029
Cannabidiol Regulates the Expression of
Keratinocyte Proteins Involved in the Inflammation Process through
Transcriptional Regulation.
Jastrząb A, Gęgotek A, Skrzydlewska E.
Cells. 2019 Aug 3;8(8). pii: E827. doi: 10.3390/cells8080827.
PMID:31382646
Free PMC Article Dose-Dependent Cannabidiol-Induced Elevation of
Intracellular Calcium and Apoptosis in Human Articular
Chondrocytes.
Winklmayr M, Gaisberger M, Kittl M, Fuchs J, Ritter M, Jakab M.
J Orthop Res. 2019 Dec;37(12):2540-2549. doi: 10.1002/jor.24430.
Epub 2019 Aug 26.
PMID:31378964
Free PMC Article Pharmacology of Medical Cannabis.
Amin MR, Ali DW.
Adv Exp Med Biol. 2019;1162:151-165. doi:
10.1007/978-3-030-21737-2_8. Review.
PMID:31332738
Cannabis and Cannabinoids on Treatment of
Inflammation: A Patent Review.
Nascimento Menezes PM, Valença Pereira EC, Gomes da Cruz Silva ME,
da Silva BAO, de Souza Duarte Filho LAM, de Lima Araújo TC, Bezerra
Lima KS, Silva FS, Rolim LA.
Recent Pat Biotechnol. 2019;13(4):256-267. doi:
10.2174/1872208313666190618124345.
PMID:31237222
Efficacy and safety of cannabidiol followed by an
open label add-on of tetrahydrocannabinol for the treatment of
chronic pain in patients with rheumatoid arthritis or ankylosing
spondylitis: protocol for a multicentre, randomised,
placebo-controlled study.
Hendricks O, Andersen TE, Christiansen AA, Primdahl J, Hauge EM,
Ellingsen T, Horsted TI, Bachmann AG, Loft AG, Bojesen AB,
Østergaard M, Lund Hetland M, Krogh NS, Roessler KK, Petersen KH.
BMJ Open. 2019 Jun 4;9(6):e028197. doi: 10.1136/bmjopen-2018-028197.
PMID:31167870
Free PMC Article Palmitoylethanolamide and Cannabidiol Prevent
Inflammation-induced Hyperpermeability of the Human Gut In Vitro
and In Vivo-A Randomized, Placebo-controlled, Double-blind
Controlled Trial.
Couch DG, Cook H, Ortori C, Barrett D, Lund JN, O'Sullivan SE.
Inflamm Bowel Dis. 2019 May 4;25(6):1006-1018. doi:
10.1093/ibd/izz017.
PMID:31054246
Cannabidiol protects livers against nonalcoholic
steatohepatitis induced by high-fat high cholesterol diet via
regulating NF-κB and NLRP3 inflammasome pathway.
Huang Y, Wan T, Pang N, Zhou Y, Jiang X, Li B, Gu Y, Huang Y, Ye X,
Lian H, Zhang Z, Yang L.
J Cell Physiol. 2019 Nov;234(11):21224-21234. doi:
10.1002/jcp.28728. Epub 2019 Apr 29.
PMID:31032942
A Novel Standardized Cannabis sativa L.
Extract and Its Constituent Cannabidiol Inhibit Human
Polymorphonuclear Leukocyte Functions.
Mabou Tagne A, Marino F, Legnaro M, Luini A, Pacchetti B, Cosentino
M.
Int J Mol Sci. 2019 Apr 13;20(8). pii: E1833. doi:
10.3390/ijms20081833.
PMID:31013912
Free PMC Article A therapeutic effect of cbd-enriched ointment in
inflammatory skin diseases and cutaneous scars.
Palmieri B, Laurino C, Vadal M.
Clin Ter. 2019 Mar-Apr;170(2):e93-e99. doi: 10.7417/CT.2019.2116.
PMID:30993303
Free Article Cannabis Oil Use by Adolescents and Young Adults
With Inflammatory Bowel Disease.
Hoffenberg EJ, McWilliams S, Mikulich-Gilbertson S, Murphy B,
Hoffenberg A, Hopfer CJ.
J Pediatr Gastroenterol Nutr. 2019 Mar;68(3):348-352. doi:
10.1097/MPG.0000000000002189.
PMID:30801394
DMH-CBD, a cannabidiol analog with reduced
cytotoxicity, inhibits TNF production by targeting NF-kB activity
dependent on A2A receptor.
Silva RL, Silveira GT, Wanderlei CW, Cecilio NT, Maganin AGM,
Franchin M, Marques LMM, Lopes NP, Crippa JA, Guimarães FS,
Alves-Filho JCF, Cunha FQ, Cunha TM.
Toxicol Appl Pharmacol. 2019 Apr 1;368:63-71. doi:
10.1016/j.taap.2019.02.011. Epub 2019 Feb 20.
PMID:30796934
Cannabidiol modulates the expression of
neuroinflammatory factors in stress- and drug-induced
reinstatement of methamphetamine in extinguished rats.
Karimi-Haghighi S, Dargahi L, Haghparast A.
Addict Biol. 2019 Feb 22. doi: 10.1111/adb.12740. [Epub ahead of
print]
PMID:30793820
miRNA expression profiles and molecular networks
in resting and LPS-activated BV-2 microglia-Effect of
cannabinoids.
Juknat A, Gao F, Coppola G, Vogel Z, Kozela E.
PLoS One. 2019 Feb 11;14(2):e0212039. doi:
10.1371/journal.pone.0212039. eCollection 2019.
PMID:30742662
Free PMC Article Cannabinoids Reduce Inflammation but Inhibit
Lymphocyte Recovery in Murine Models of Bone Marrow
Transplantation.
Khuja I, Yekhtin Z, Or R, Almogi-Hazan O.
Int J Mol Sci. 2019 Feb 4;20(3). pii: E668. doi:
10.3390/ijms20030668.
PMID:30720730
Free PMC Article Oral cannabinoids in people living with HIV on
effective antiretroviral therapy: CTN PT028-study protocol for a
pilot randomised trial to assess safety, tolerability and effect
on immune activation.
Costiniuk CT, Saneei Z, Routy JP, Margolese S, Mandarino E, Singer
J, Lebouché B, Cox J, Szabo J, Brouillette MJ, Klein MB, Chomont N,
Jenabian MA.
BMJ Open. 2019 Jan 17;9(1):e024793. doi:
10.1136/bmjopen-2018-024793.
PMID:30659041
Free PMC Article Cannabis sativa L. and Nonpsychoactive
Cannabinoids: Their Chemistry and Role against Oxidative Stress,
Inflammation, and Cancer. Pellati F, Borgonetti V, Brighenti
V, Biagi M, Benvenuti S, Corsi L.
Biomed Res Int. 2018 Dec 4;2018:1691428. doi: 10.1155/2018/1691428.
eCollection 2018. Review.
PMID:30627539
Free PMC Article The Anti-Inflammatory Properties of Terpenoids
from Cannabis.
Gallily R, Yekhtin Z, Hanuš LO.
Cannabis Cannabinoid Res. 2018 Dec 26;3(1):282-290. doi:
10.1089/can.2018.0014. eCollection 2018.
PMID:30596146
Free PMC Article Cannabidiol reduces airway inflammation and
fibrosis in experimental allergic asthma.
Vuolo F, Abreu SC, Michels M, Xisto DG, Blanco NG, Hallak JE, Zuardi
AW, Crippa JA, Reis C, Bahl M, Pizzichinni E, Maurici R, Pizzichinni
MMM, Rocco PRM, Dal-Pizzol F.
Eur J Pharmacol. 2019 Jan 15;843:251-259. doi:
10.1016/j.ejphar.2018.11.029. Epub 2018 Nov 24.
PMID:30481497
Quantification of Eight Cannabinoids Including
Cannabidiol in Human Urine Via Liquid Chromatography Tandem Mass
Spectrometry.
Scheidweiler KB, Barnes AJ.
Methods Mol Biol. 2019;1872:11-22. doi: 10.1007/978-1-4939-8823-5_2.
PMID:30350275
Effect of cannabidiolic acid and ∆9-tetrahydrocannabinol
on carrageenan-induced hyperalgesia and edema in a rodent model of
inflammatory pain.
Rock EM, Limebeer CL, Parker LA.
Psychopharmacology (Berl). 2018 Nov;235(11):3259-3271. doi:
10.1007/s00213-018-5034-1. Epub 2018 Sep 17.
PMID:30225659
Cannabidiol prevents haloperidol-induced vacuos
chewing movements and inflammatory changes in mice via PPARγ
receptors.
Sonego AB, Prado DS, Vale GT, Sepulveda-Diaz JE, Cunha TM, Tirapelli
CR, Del Bel EA, Raisman-Vozari R, Guimarães FS.
Brain Behav Immun. 2018 Nov;74:241-251. doi:
10.1016/j.bbi.2018.09.014. Epub 2018 Sep 11.
PMID:30217539
Medicinal Properties of Cannabinoids, Terpenes,
and Flavonoids in Cannabis, and Benefits in Migraine, Headache,
and Pain: An Update on Current Evidence and Cannabis Science.
Baron EP.
Headache. 2018 Jul;58(7):1139-1186. doi: 10.1111/head.13345. Review.
PMID:30152161
Untargeted rat brain metabolomics after oral
administration of a single high dose of cannabidiol.
Citti C, Palazzoli F, Licata M, Vilella A, Leo G, Zoli M, Vandelli
MA, Forni F, Pacchetti B, Cannazza G.
J Pharm Biomed Anal. 2018 Nov 30;161:1-11. doi:
10.1016/j.jpba.2018.08.021. Epub 2018 Aug 11.
PMID:30138822
Cannabidiol Attenuates Experimental Autoimmune
Encephalomyelitis Model of Multiple Sclerosis Through Induction of
Myeloid-Derived Suppressor Cells.
Elliott DM, Singh N, Nagarkatti M, Nagarkatti PS.
Front Immunol. 2018 Aug 3;9:1782. doi: 10.3389/fimmu.2018.01782.
eCollection 2018.
PMID:30123217
Free PMC Article Patterns of medicinal cannabis use, strain
analysis, and substitution effect among patients with migraine,
headache, arthritis, and chronic pain in a medicinal cannabis
cohort.
Baron EP, Lucas P, Eades J, Hogue O.
J Headache Pain. 2018 May 24;19(1):37. doi:
10.1186/s10194-018-0862-2.
PMID:29797104
Free PMC Article
The non-psychoactive phytocannabinoid cannabidiol
(CBD) attenuates pro-inflammatory mediators, T cell infiltration,
and thermal sensitivity following spinal cord injury in mice.
Li H, Kong W, Chambers CR, Yu D, Ganea D, Tuma RF, Ward SJ.
Cell Immunol. 2018 Jul;329:1-9. doi: 10.1016/j.cellimm.2018.02.016.
Epub 2018 Mar 8.
PMID:29784129
Free PMC Article Is Cannabidiol a Promising Substance for New Drug
Development? A Review of its Potential Therapeutic Applications.
Noreen N, Muhammad F, Akhtar B, Azam F, Anwar MI.
Crit Rev Eukaryot Gene Expr. 2018;28(1):73-86. doi:
10.1615/CritRevEukaryotGeneExpr.2018021528. Review.
PMID:29773016
Anti-inflammatory Properties of Cannabidiol, a
Nonpsychotropic Cannabinoid, in Experimental Allergic Contact
Dermatitis.
Petrosino S, Verde R, Vaia M, Allar M, Iuvone T, Di Marzo V.
J Pharmacol Exp Ther. 2018 Jun;365(3):652-663. doi:
10.1124/jpet.117.244368. Epub 2018 Apr 9.
PMID:29632236
Maternal administration of cannabidiol promotes an
anti-inflammatory effect on the intestinal wall in a gastroschisis
rat model.
Callejas GH, Figueira RL, Gonçalves FLL, Volpe FAP, Zuardi AW,
Crippa JA, Hallak JE, Sbragia L.
Braz J Med Biol Res. 2018 Mar 15;51(5):e7132. doi:
10.1590/1414-431X20177132.
PMID:29561958
Free PMC Article A Randomized, Double-blind, Placebo-controlled,
Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract
in the Symptomatic Treatment of Ulcerative Colitis.
Irving PM, Iqbal T, Nwokolo C, Subramanian S, Bloom S, Prasad N,
Hart A, Murray C, Lindsay JO, Taylor A, Barron R, Wright S.
Inflamm Bowel Dis. 2018 Mar 19;24(4):714-724. doi:
10.1093/ibd/izy002.
PMID:29538683
Hypoxia mimetic activity of VCE-004.8, a
cannabidiol quinone derivative: implications for multiple
sclerosis therapy.
Navarrete C, Carrillo-Salinas F, Palomares B, Mecha M,
Jiménez-Jiménez C, Mestre L, Feliú A, Bellido ML, Fiebich BL,
Appendino G, Calzado MA, Guaza C, Muñoz E.
J Neuroinflammation. 2018 Mar 1;15(1):64. doi:
10.1186/s12974-018-1103-y.
PMID:29495967
Free PMC Article The Cannabinoids Δ8THC, CBD, and
HU-308 Act via Distinct Receptors to Reduce Corneal Pain and
Inflammation.
Thapa D, Cairns EA, Szczesniak AM, Toguri JT, Caldwell MD, Kelly
MEM.
Cannabis Cannabinoid Res. 2018 Feb 1;3(1):11-20. doi:
10.1089/can.2017.0041. eCollection 2018.
PMID:29450258
Free PMC Article Involvement of glycine receptor α1 subunits in
cannabinoid-induced analgesia.
Lu J, Fan S, Zou G, Hou Y, Pan T, Guo W, Yao L, Du F, Homanics
GE, Liu D, Zhang L, Xiong W.
Neuropharmacology. 2018 May 1;133:224-232. doi:
10.1016/j.neuropharm.2018.01.041. Epub 2018 Feb 1.
PMID:29407767
Practical considerations in medical cannabis
administration and dosing.
MacCallum CA, Russo EB.
Eur J Intern Med. 2018 Mar;49:12-19. doi:
10.1016/j.ejim.2018.01.004. Epub 2018 Jan 4. Review.
PMID:29307505
Current evidence of cannabinoid-based analgesia
obtained in preclinical and human experimental settings.
Lötsch J, Weyer-Menkhoff I, Tegeder I.
Eur J Pain. 2018 Mar;22(3):471-484. doi: 10.1002/ejp.1148. Epub 2017
Nov 21. Review.
PMID:29160600
Single-Dose Pharmacokinetics of Oral Cannabidiol
Following Administration of PTL101: A New Formulation Based on
Gelatin Matrix Pellets Technology.
Atsmon J, Heffetz D, Deutsch L, Deutsch F, Sacks H.
Clin Pharmacol Drug Dev. 2018 Sep;7(7):751-758. doi:
10.1002/cpdd.408. Epub 2017 Nov 10.
PMID:29125702
Translating Endocannabinoid Biology into Clinical
Practice: Cannabidiol for Stroke Prevention.
Scharf EL.
Cannabis Cannabinoid Res. 2017 Oct 1;2(1):259-264. doi:
10.1089/can.2017.0033. eCollection 2017. Review.
PMID:29098188
Free PMC Article Anti-Inflammatory Activity in Colon Models Is
Derived from Δ9-Tetrahydrocannabinolic Acid That Interacts with
Additional Compounds in Cannabis Extracts.
Nallathambi R, Mazuz M, Ion A, Selvaraj G, Weininger S, Fridlender
M, Nasser A, Sagee O, Kumari P, Nemichenizer D, Mendelovitz M,
Firstein N, Hanin O, Konikoff F, Kapulnik Y, Naftali T, Koltai H.
Cannabis Cannabinoid Res. 2017 Jul 1;2(1):167-182. doi:
10.1089/can.2017.0027. eCollection 2017.
PMID:29082314
Free PMC Article Effects of cannabidiol interactions with
Wnt/β-catenin pathway and PPARγ on oxidative stress and
neuroinflammation in Alzheimer's disease.
Vallée A, Lecarpentier Y, Guillevin R, Vallée JN.
Acta Biochim Biophys Sin (Shanghai). 2017 Oct 1;49(10):853-866. doi:
10.1093/abbs/gmx073.
PMID:28981597
Is cannabis an effective treatment for joint pain?
Miller RJ, Miller RE.
Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):59-67. Epub 2017
Sep 28. Review.
PMID:28967368
Free Article Cannabidiol and palmitoylethanolamide are
anti-inflammatory in the acutely inflamed human colon.
Couch DG, Tasker C, Theophilidou E, Lund JN, O'Sullivan SE.
Clin Sci (Lond). 2017 Oct 25;131(21):2611-2626. doi:
10.1042/CS20171288. Print 2017 Nov 1.
PMID:28954820
Cannabidiol attenuates alcohol-induced liver
steatosis, metabolic dysregulation, inflammation and
neutrophil-mediated injury.
Wang Y, Mukhopadhyay P, Cao Z, Wang H, Feng D, Haskó G, Mechoulam
R, Gao B, Pacher P.
Sci Rep. 2017 Sep 21;7(1):12064. doi: 10.1038/s41598-017-10924-8.
PMID:28935932
Free PMC Article Attenuation of early phase inflammation by
cannabidiol prevents pain and nerve damage in rat osteoarthritis.
Philpott HT, OʼBrien M, McDougall JJ.
Pain. 2017 Dec;158(12):2442-2451. doi:
10.1097/j.pain.0000000000001052.
PMID:28885454
Free PMC Article Intra-cerebral cannabidiol infusion-induced
neuroprotection is partly associated with the TNF-α/TNFR1/NF-кB
pathway in transient focal cerebral ischaemia.
Khaksar S, Bigdeli MR.
Brain Inj. 2017;31(13-14):1932-1943. doi:
10.1080/02699052.2017.1358397. Epub 2017 Sep 5.
PMID:28872345
Mechanisms of action of cannabidiol in adoptively
transferred experimental autoimmune encephalomyelitis.
González-García C, Torres IM, García-Hernández R, Campos-Ruíz
L, Esparragoza LR, Coronado MJ, Grande AG, García-Merino A,
Sánchez López AJ.
Exp Neurol. 2017 Dec;298(Pt A):57-67. doi:
10.1016/j.expneurol.2017.08.017. Epub 2017 Sep 1.
PMID:28867485
GPR55: A therapeutic target for Parkinson's
disease?
Celorrio M, Rojo-Bustamante E, Fernández-Suárez D, Sáez E,
Estella-Hermoso de Mendoza A, Müller CE, Ramírez MJ, Oyarzábal J,
Franco R, Aymerich MS.
Neuropharmacology. 2017 Oct;125:319-332. doi:
10.1016/j.neuropharm.2017.08.017. Epub 2017 Aug 12.
PMID:28807673
Antinociceptive effects of HUF-101, a fluorinated
cannabidiol derivative.
Silva NR, Gomes FV, Fonseca MD, Mechoulam R, Breuer A, Cunha TM,
Guimarães FS.
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt
B):369-377. doi: 10.1016/j.pnpbp.2017.07.012. Epub 2017 Jul 15.
PMID:28720466
An Overview on Medicinal Chemistry of Synthetic
and Natural Derivatives of Cannabidiol.
Morales P, Reggio PH, Jagerovic N.
Front Pharmacol. 2017 Jun 28;8:422. doi: 10.3389/fphar.2017.00422.
eCollection 2017. Review.
PMID:28701957
Free PMC Article Cannabidiol in medical marijuana: Research vistas
and potential opportunities.
Rong C, Lee Y, Carmona NE, Cha DS, Ragguett RM, Rosenblat JD, Mansur
RB, Ho RC, McIntyre RS.
Pharmacol Res. 2017 Jul;121:213-218. doi:
10.1016/j.phrs.2017.05.005. Epub 2017 May 10. Review.
PMID:28501518
Cannabidiol reduces lung injury induced by
hypoxic-ischemic brain damage in newborn piglets.
Arruza L, Pazos MR, Mohammed N, Escribano N, Lafuente H, Santos M,
Alvarez-Díaz FJ, Hind W, Martínez-Orgado J.
Pediatr Res. 2017 Jul;82(1):79-86. doi: 10.1038/pr.2017.104. Epub
2017 May 3.
PMID:28388598
Improved Social Interaction, Recognition and
Working Memory with Cannabidiol Treatment in a Prenatal Infection
(poly I:C) Rat Model.
Osborne AL, Solowij N, Babic I, Huang XF, Weston-Green K.
Neuropsychopharmacology. 2017 Jun;42(7):1447-1457. doi:
10.1038/npp.2017.40. Epub 2017 Feb 23.
PMID:28230072
Free PMC Article In vivo Evidence for Therapeutic Properties
of Cannabidiol (CBD) for Alzheimer's Disease.
Watt G, Karl T.
Front Pharmacol. 2017 Feb 3;8:20. doi: 10.3389/fphar.2017.00020.
eCollection 2017. Review.
PMID:28217094
Free PMC Article Cannabidiol Modulates the Immunophenotype and
Inhibits the Activation of the Inflammasome in Human Gingival
Mesenchymal Stem Cells. Libro R, Scionti D, Diomede F,
Marchisio M, Grassi G, Pollastro F, Piattelli A, Bramanti P, Mazzon
E, Trubiani O.
Front Physiol. 2016 Nov 24;7:559. eCollection 2016.
PMID:27932991
Free PMC Article A systematic review of the effect of cannabidiol
on cognitive function: Relevance to schizophrenia.
Osborne AL, Solowij N, Weston-Green K.
Neurosci Biobehav Rev. 2017 Jan;72:310-324. doi:
10.1016/j.neubiorev.2016.11.012. Epub 2016 Nov 22. Review.
PMID:27884751
Cannabinoid Buccal Spray for Chronic Non-Cancer or
Neuropathic Pain: A Review of Clinical Effectiveness, Safety, and
Guidelines [Internet].
Ottawa (ON): Canadian Agency for Drugs and Technologies in Health;
2016 Sep 21.
PMID:27831665
Free Books & Documents Experimental cannabidiol treatment
reduces early pancreatic inflammation in type 1
diabetes.
Lehmann C, Fisher NB, Tugwell B, Szczesniak A, Kelly M, Zhou J.
Clin Hemorheol Microcirc. 2016;64(4):655-662. doi:
10.3233/CH-168021.
PMID:27767974
An Orally Active Cannabis Extract with
High Content in Cannabidiol attenuates Chemically-induced
Intestinal Inflammation and Hypermotility in the Mouse.
Pagano E, Capasso R, Piscitelli F, Romano B, Parisi OA, Finizio S,
Lauritano A, Marzo VD, Izzo AA, Borrelli F.
Front Pharmacol. 2016 Oct 4;7:341. eCollection 2016.
PMID:27757083
Free PMC Article The therapeutic potential of the phytocannabinoid
cannabidiol for Alzheimer's disease.
Karl T, Garner B, Cheng D.
Behav Pharmacol. 2017 Apr;28(2 and 3-Spec Issue):142-160. doi:
10.1097/FBP.0000000000000247. Review.
PMID:27471947
Abnormal cannabidiol attenuates experimental
colitis in mice, promotes wound healing and inhibits neutrophil
recruitment.
Krohn RM, Parsons SA, Fichna J, Patel KD, Yates RM, Sharkey KA,
Storr MA.
J Inflamm (Lond). 2016 Jul 14;13:21. doi: 10.1186/s12950-016-0129-0.
eCollection 2016.
PMID:27418880
Free PMC Article Anti-inflammatory and antioxidant effects of a
combination of cannabidiol and moringin in LPS-stimulated
macrophages.
Rajan TS, Giacoppo S, Iori R, De Nicola GR, Grassi G, Pollastro F,
Bramanti P, Mazzon E.
Fitoterapia. 2016 Jul;112:104-15. doi: 10.1016/j.fitote.2016.05.008.
Epub 2016 May 20.
PMID:27215129
The cannabinoid quinol VCE-004.8 alleviates
bleomycin-induced scleroderma and exerts potent antifibrotic
effects through peroxisome proliferator-activated receptor-γ and
CB2 pathways.
del Río C, Navarrete C, Collado JA, Bellido ML, Gómez-Cañas M,
Pazos MR, Fernández-Ruiz J, Pollastro F, Appendino G, Calzado MA,
Cantarero I, Muñoz E.
Sci Rep. 2016 Feb 18;6:21703. doi: 10.1038/srep21703.
PMID:26887982
Free PMC Article Cannabidiol Limits T Cell-Mediated Chronic
Autoimmune Myocarditis: Implications to Autoimmune Disorders and
Organ Transplantation.
Lee WS, Erdelyi K, Matyas C, Mukhopadhyay P, Varga ZV, Liaudet L,
Haskú G, Čiháková D, Mechoulam R, Pacher P.
Mol Med. 2016 Sep;22:136-146. doi: 10.2119/molmed.2016.00007. Epub
2016 Jan 8.
PMID:26772776
Free PMC Article Purified Cannabidiol, the main non-psychotropic
component of Cannabis sativa, alone, counteracts neuronal
apoptosis in experimental multiple sclerosis.
Giacoppo S, Soundara Rajan T, Galuppo M, Pollastro F, Grassi G,
Bramanti P, Mazzon E.
Eur Rev Med Pharmacol Sci. 2015 Dec;19(24):4906-19.
PMID:26744883
Free Article
The neuroprotection of cannabidiol against
MPP⁺-induced toxicity in PC12 cells involves trkA receptors,
upregulation of axonal and synaptic proteins, neuritogenesis, and
might be relevant to Parkinson's disease.
Santos NA, Martins NM, Sisti FM, Fernandes LS, Ferreira RS, Queiroz
RH, Santos AC.
Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):231-40. doi:
10.1016/j.tiv.2015.11.004. Epub 2015 Nov 7.
PMID:26556726
Free Article Anti-inflammatory effects of the cannabidiol
derivative dimethylheptyl-cannabidiol - studies in BV-2 microglia
and encephalitogenic T cells.
Juknat A, Kozela E, Kaushansky N, Mechoulam R, Vogel Z.
J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):289-96. doi:
10.1515/jbcpp-2015-0071.
PMID:26540221
Free Article Transdermal cannabidiol reduces inflammation and
pain-related behaviours in a rat model of arthritis.
Hammell DC, Zhang LP, Ma F, Abshire SM, McIlwrath SL, Stinchcomb AL,
Westlund KN.
Eur J Pain. 2016 Jul;20(6):936-48. doi: 10.1002/ejp.818. Epub 2015
Oct 30.
PMID:26517407
Free PMC Article A new formulation of cannabidiol in cream shows
therapeutic effects in a mouse model of experimental autoimmune
encephalomyelitis. Giacoppo S, Galuppo M, Pollastro F, Grassi
G, Bramanti P, Mazzon E.
Daru. 2015 Oct 21;23:48. doi: 10.1186/s40199-015-0131-8.
PMID:26489494
Free PMC Article HU-444, a Novel, Potent Anti-Inflammatory,
Nonpsychotropic Cannabinoid.
Haj CG, Sumariwalla PF, Hanuš L, Kogan NM, Yektin Z, Mechoulam R,
Feldmann M, Gallily R.
J Pharmacol Exp Ther. 2015 Oct;355(1):66-75. doi:
10.1124/jpet.115.226100. Epub 2015 Aug 13.
PMID:26272937
Free PMC Article HU-446 and HU-465, Derivatives of the
Non-psychoactive Cannabinoid Cannabidiol, Decrease the Activation
of Encephalitogenic T Cells.
Kozela E, Haj C, Hanuš L, Chourasia M, Shurki A, Juknat A,
Kaushansky N, Mechoulam R, Vogel Z.
Chem Biol Drug Des. 2016 Jan;87(1):143-53. doi: 10.1111/cbdd.12637.
Epub 2015 Sep 16.
PMID:26259697
Evaluation of Serum Cytokines Levels and the Role
of Cannabidiol Treatment in Animal Model of Asthma.
Vuolo F, Petronilho F, Sonai B, Ritter C, Hallak JE, Zuardi AW,
Crippa JA, Dal-Pizzol F.
Mediators Inflamm. 2015;2015:538670. doi: 10.1155/2015/538670. Epub
2015 May 25.
PMID:26101464
Free PMC Article Pharmacologic Effects of Cannabidiol on Acute
Reperfused Myocardial Infarction in Rabbits: Evaluated With 3.0T
Cardiac Magnetic Resonance Imaging and Histopathology.
Feng Y, Chen F, Yin T, Xia Q, Liu Y, Huang G, Zhang J, Oyen R, Ni Y.
J Cardiovasc Pharmacol. 2015 Oct;66(4):354-63. doi:
10.1097/FJC.0000000000000287.
PMID:26065843
Cannabidiol for the Prevention of
Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell
Transplantation: Results of a Phase II Study.
Yeshurun M, Shpilberg O, Herscovici C, Shargian L, Dreyer J, Peck A,
Israeli M, Levy-Assaraf M, Gruenewald T, Mechoulam R, Raanani P, Ram
R.
Biol Blood Marrow Transplant. 2015 Oct;21(10):1770-5. doi:
10.1016/j.bbmt.2015.05.018. Epub 2015 May 30.
PMID:26033282
Free Articles Cannabidiol rescues acute hepatic toxicity and
seizure induced by cocaine.
Vilela LR, Gomides LF, David BA, Antunes MM, Diniz AB, Moreira Fde
A, Menezes GB.
Mediators Inflamm. 2015;2015:523418. doi: 10.1155/2015/523418. Epub
2015 Apr 27.
PMID:25999668
Free PMC Article Lipid metabolism and inflammation modulated by
Vitamin D in liver of diabetic rats.
Ning C, Liu L, Lv G, Yang Y, Zhang Y, Yu R, Wang Y, Zhu J.
Lipids Health Dis. 2015 Apr 18;14:31. doi:
10.1186/s12944-015-0030-5.
PMID:25899686
Free PMC Article Cannabidiol, a non-psychoactive cannabinoid, leads
to EGR2-dependent anergy in activated encephalitogenic T cells.
Kozela E, Juknat A, Kaushansky N, Ben-Nun A, Coppola G, Vogel Z.
J Neuroinflammation. 2015 Mar 15;12:52. doi:
10.1186/s12974-015-0273-0.
PMID:25880134
Free PMC Article