Cannabidiol Administration Prevents Hypoxia-Ischemia-Induced Hypomyelination in Newborn Rats.Ceprián M, Vargas C, García-Toscano L, Penna F, Jiménez-Sánchez L, Achicallende S, Elezgarai I, Grandes P, Hind W, Pazos MR, Martínez-Orgado J.
Front Pharmacol. 2019 Sep 26;10:1131. doi: 10.3389/fphar.2019.01131. eCollection 2019.PMID:31611802
Free PMC ArticleCannabidiol improves metabolic dysfunction in middle-aged diabetic rats submitted to a chronic cerebral hypoperfusion.Zorzenon MRT, Santiago AN, Mori MA, Piovan S, Jansen CA, Perina Padilha ME, Ciotta SR, Cezar de Freitas Mathias P, Guimarães FS, Weffort de Oliveira RM, Milani PG, Mareze-Costa CE.
Chem Biol Interact. 2019 Oct 1;312:108819. doi: 10.1016/j.cbi.2019.108819. Epub 2019 Sep 6.PMID:31499052Cannabidiol improves vocal learning-dependent recovery from, and reduces magnitude of deficits following, damage to a cortical-like brain region in a songbird pre-clinical animal model.Alalawi A, Dodu JC, Woolley-Roberts M, Brodie J, Di Marzo V, Soderstrom K.
Neuropharmacology. 2019 Nov 1;158:107716. doi: 10.1016/j.neuropharm.2019.107716. Epub 2019 Jul 17.PMID:31325430Effects of Cannabidiol on Diabetes Outcomes and Chronic Cerebral Hypoperfusion Comorbidities in Middle-Aged Rats.Santiago AN, Mori MA, Guimarães FS, Milani H, Weffort de Oliveira RM.
Neurotox Res. 2019 Feb;35(2):463-474. doi: 10.1007/s12640-018-9972-5. Epub 2018 Nov 14.PMID:30430393Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.Rodríguez-Muñoz M, Onetti Y, Cortés-Montero E, Garzón J, Sánchez-Blázquez P.
Mol Brain. 2018 Sep 17;11(1):51. doi: 10.1186/s13041-018-0395-2.PMID:30223868
Free PMC ArticleIntra-cerebral cannabidiol infusion-induced neuroprotection is partly associated with the TNF-α/TNFR1/NF-кB pathway in transient focal cerebral ischaemia.Khaksar S, Bigdeli MR.
Brain Inj. 2017;31(13-14):1932-1943. doi: 10.1080/02699052.2017.1358397. Epub 2017 Sep 5.PMID:28872345Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid.Kozela E, Juknat A, Vogel Z.
Int J Mol Sci. 2017 Jul 31;18(8). pii: E1669. doi: 10.3390/ijms18081669. Review.PMID:28788104
Free PMC ArticleHigh-Dose Cannabidiol Induced Hypotension after Global Hypoxia-Ischemia in Piglets.Garberg HT, Solberg R, Barlinn J, Martinez-Orgado J, Løberg EM, Saugstad OD.
Neonatology. 2017;112(2):143-149. doi: 10.1159/000471786. Epub 2017 Jun 1.PMID:28564654Neurological Aspects of Medical Use of Cannabidiol.Mannucci C, Navarra M, Calapai F, Spagnolo EV, Busardò FP, Cas RD, Ippolito FM, Calapai G.
CNS Neurol Disord Drug Targets. 2017;16(5):541-553. doi: 10.2174/1871527316666170413114210. Review.PMID:28412918Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons.Sun S, Hu F, Wu J, Zhang S.
Redox Biol. 2017 Apr;11:577-585. doi: 10.1016/j.redox.2016.12.029. Epub 2016 Dec 31.PMID:28110213
Free PMC ArticleCannabidiol reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke.Ceprián M, Jiménez-Sánchez L, Vargas C, Barata L, Hind W, Martínez-Orgado J.
Neuropharmacology. 2017 Apr;116:151-159. doi: 10.1016/j.neuropharm.2016.12.017. Epub 2016 Dec 21.PMID:28012949Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia.Mori MA, Meyer E, Soares LM, Milani H, Guimarães FS, de Oliveira RMW.
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:94-105. doi: 10.1016/j.pnpbp.2016.11.005. Epub 2016 Nov 23.PMID:27889412Anti-excitotoxic effects of cannabidiol are partly mediated by enhancement of NCX2 and NCX3 expression in animal model of cerebral ischemia.Khaksar S, Bigdeli MR.
Eur J Pharmacol. 2017 Jan 5;794:270-279. doi: 10.1016/j.ejphar.2016.11.011. Epub 2016 Nov 14.PMID:27856160Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets.Garberg HT, Huun MU, Escobar J, Martinez-Orgado J, Løberg EM, Solberg R, Didrik Saugstad O.
Pediatr Res. 2016 Nov;80(5):710-718. doi: 10.1038/pr.2016.149. Epub 2016 Jul 21.PMID:27441365Neuroprotective Effects of Cannabidiol in Hypoxic Ischemic Insult. The Therapeutic Window in Newborn Mice.Mohammed N, Ceprian M, Jimenez L, Pazos MR, Martínez-Orgado J.
CNS Neurol Disord Drug Targets. 2017;16(1):102-108. doi: 10.2174/1871527315666160927110305.PMID:27686886Cannabidiol protects an in vitro model of the blood-brain barrier from oxygen-glucose deprivation via PPARγ and 5-HT1A receptors.Hind WH, England TJ, O'Sullivan SE.
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Free PMC ArticleCannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.Devinsky O, Cilio MR, Cross H, Fernandez-Ruiz J, French J, Hill C, Katz R, Di Marzo V, Jutras-Aswad D, Notcutt WG, Martinez-Orgado J, Robson PJ, Rohrback BG, Thiele E, Whalley B, Friedman D.
Epilepsia. 2014 Jun;55(6):791-802. doi: 10.1111/epi.12631. Epub 2014 May 22. Review.PMID:24854329
Free PMC ArticleProtective effects of cannabidiol against hippocampal cell death and cognitive impairment induced by bilateral common carotid artery occlusion in mice.Schiavon AP, Soares LM, Bonato JM, Milani H, Guimarães FS, Weffort de Oliveira RM.
Neurotox Res. 2014 Nov;26(4):307-16. doi: 10.1007/s12640-014-9457-0. Epub 2014 Feb 15.PMID:24532152Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors.Pazos MR, Mohammed N, Lafuente H, Santos M, Martínez-Pinilla E, Moreno E, Valdizan E, Romero J, Pazos A, Franco R, Hillard CJ, Alvarez FJ, Martínez-Orgado J.
Neuropharmacology. 2013 Aug;71:282-91. doi: 10.1016/j.neuropharm.2013.03.027. Epub 2013 Apr 12.PMID:23587650Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function.Pazos MR, Cinquina V, Gómez A, Layunta R, Santos M, Fernández-Ruiz J, Martínez-Orgado J.
Neuropharmacology. 2012 Oct;63(5):776-83. doi: 10.1016/j.neuropharm.2012.05.034. Epub 2012 May 30.PMID:22659086Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?Fernández-Ruiz J, Sagredo O, Pazos MR, García C, Pertwee R, Mechoulam R, Martínez-Orgado J.
Br J Clin Pharmacol. 2013 Feb;75(2):323-33. doi: 10.1111/j.1365-2125.2012.04341.x. Review.PMID:22625422
Free PMC ArticleCannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs.Lafuente H, Alvarez FJ, Pazos MR, Alvarez A, Rey-Santano MC, Mielgo V, Murgia-Esteve X, Hilario E, Martinez-Orgado J.
Pediatr Res. 2011 Sep;70(3):272-7. doi: 10.1203/PDR.0b013e3182276b11.PMID:21654550The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors.Castillo A, Tolón MR, Fernández-Ruiz J, Romero J, Martinez-Orgado J.
Neurobiol Dis. 2010 Feb;37(2):434-40. doi: 10.1016/j.nbd.2009.10.023. Epub 2009 Nov 6.PMID:19900555Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets.Alvarez FJ, Lafuente H, Rey-Santano MC, Mielgo VE, Gastiasoro E, Rueda M, Pertwee RG, Castillo AI, Romero J, Martínez-Orgado J.
Pediatr Res. 2008 Dec;64(6):653-8. doi: 10.1203/PDR.0b013e318186e5dd.PMID:18679164Cannabidiol--recent advances.Mechoulam R, Peters M, Murillo-Rodriguez E, Hanus LO.
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