Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol.Mammana S, Cavalli E, Gugliandolo A, Silvestro S, Pollastro F, Bramanti P, Mazzon E.
Medicina (Kaunas). 2019 Nov 18;55(11). pii: E747. doi: 10.3390/medicina55110747.PMID:31752240
Free PMC ArticleCannabidiol improves metabolic dysfunction in middle-aged diabetic rats submitted to a chronic cerebral hypoperfusion.Zorzenon MRT, Santiago AN, Mori MA, Piovan S, Jansen CA, Perina Padilha ME, Ciotta SR, Cezar de Freitas Mathias P, Guimarães FS, Weffort de Oliveira RM, Milani PG, Mareze-Costa CE.
Chem Biol Interact. 2019 Oct 1;312:108819. doi: 10.1016/j.cbi.2019.108819. Epub 2019 Sep 6.PMID:31499052Cannabinoids Δ9-tetrahydrocannabinol and cannabidiol may be effective against methamphetamine induced mitochondrial dysfunction and inflammation by modulation of Toll-like type-4(Toll-like 4) receptors and NF-κB signaling.Majdi F, Taheri F, Salehi P, Motaghinejad M, Safari S.
Med Hypotheses. 2019 Dec;133:109371. doi: 10.1016/j.mehy.2019.109371. Epub 2019 Aug 19.PMID:31465975Pharmacology of Medical Cannabis.Amin MR, Ali DW.
Adv Exp Med Biol. 2019;1162:151-165. doi: 10.1007/978-3-030-21737-2_8. Review.PMID:31332738Biological bases for a possible effect of cannabidiol in Parkinson's disease.Ferreira-Junior NC, Campos AC, Guimarães FS, Del-Bel E, Zimmermann PMDR, Brum Junior L, Hallak JE, Crippa JA, Zuardi AW.
Braz J Psychiatry. 2019 Jul 15. pii: S1516-44462019005012104. doi: 10.1590/1516-4446-2019-0460. [Epub ahead of print]PMID:31314869
Free ArticlePreclinical safety and efficacy of cannabidivarin for early life seizures.Huizenga MN, Sepulveda-Rodriguez A, Forcelli PA.
Neuropharmacology. 2019 Apr;148:189-198. doi: 10.1016/j.neuropharm.2019.01.002. Epub 2019 Jan 10.PMID:30633929Neuronal preservation and reactive gliosis attenuation following neonatal sciatic nerve axotomy by a fluorinated cannabidiol derivative.Perez M, Cartarozzi LP, Chiarotto GB, Oliveira SA, Guimarães FS, Oliveira ALR.
Neuropharmacology. 2018 Sep 15;140:201-208. doi: 10.1016/j.neuropharm.2018.08.009. Epub 2018 Aug 7.PMID:30096328Cannabidiol Reverses Deficits in Hippocampal LTP in a Model of Alzheimer's Disease.Hughes B, Herron CE.
Neurochem Res. 2019 Mar;44(3):703-713. doi: 10.1007/s11064-018-2513-z. Epub 2018 Mar 24.PMID:29574668Novel insights into mitochondrial molecular targets of iron-induced neurodegeneration: Reversal by cannabidiol.da Silva VK, de Freitas BS, Dornelles VC, Kist LW, Bogo MR, Silva MC, Streck EL, Hallak JE, Zuardi AW, Crippa JAS, Schröder N.
Brain Res Bull. 2018 May;139:1-8. doi: 10.1016/j.brainresbull.2018.01.014. Epub 2018 Jan 31.PMID:29374603
Free ArticleAttenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.Philpott HT, OʼBrien M, McDougall JJ.
Pain. 2017 Dec;158(12):2442-2451. doi: 10.1097/j.pain.0000000000001052.PMID:28885454
Free PMC ArticleModulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid.Kozela E, Juknat A, Vogel Z.
Int J Mol Sci. 2017 Jul 31;18(8). pii: E1669. doi: 10.3390/ijms18081669. Review.PMID:28788104
Free PMC ArticlePlastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders.Campos AC, Fogaça MV, Scarante FF, Joca SRL, Sales AJ, Gomes FV, Sonego AB, Rodrigues NS, Galve-Roperh I, Guimarães FS.
Front Pharmacol. 2017 May 23;8:269. doi: 10.3389/fphar.2017.00269. eCollection 2017. Review.PMID:28588483
Free PMC ArticleProtective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy.Do Val-da Silva RA, Peixoto-Santos JE, Kandratavicius L, De Ross JB, Esteves I, De Martinis BS, Alves MN, Scandiuzzi RC, Hallak JE, Zuardi AW, Crippa JA, Leite JP.
Front Pharmacol. 2017 Mar 17;8:131. doi: 10.3389/fphar.2017.00131. eCollection 2017.PMID:28367124
Free PMC ArticleCannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia.Mori MA, Meyer E, Soares LM, Milani H, Guimarães FS, de Oliveira RMW.
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:94-105. doi: 10.1016/j.pnpbp.2016.11.005. Epub 2016 Nov 23.PMID:27889412A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia.Osborne AL, Solowij N, Weston-Green K.
Neurosci Biobehav Rev. 2017 Jan;72:310-324. doi: 10.1016/j.neubiorev.2016.11.012. Epub 2016 Nov 22. Review.PMID:27884751The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer's disease.Karl T, Garner B, Cheng D.
Behav Pharmacol. 2017 Apr;28(2 and 3-Spec Issue):142-160. doi: 10.1097/FBP.0000000000000247. Review.PMID:27471947Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL/6 mice.Rahimi A, Faizi M, Talebi F, Noorbakhsh F, Kahrizi F, Naderi N.
Neuroscience. 2015 Apr 2;290:279-87. doi: 10.1016/j.neuroscience.2015.01.030. Epub 2015 Jan 28.PMID:25637488Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons.Laprairie RB, Bagher AM, Kelly ME, Dupré DJ, Denovan-Wright EM.
J Biol Chem. 2014 Sep 5;289(36):24845-62. doi: 10.1074/jbc.M114.557025. Epub 2014 Jul 18.PMID:25037227
Free PMC ArticleChronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice.Cheng D, Low JK, Logge W, Garner B, Karl T.
Psychopharmacology (Berl). 2014 Aug;231(15):3009-17. doi: 10.1007/s00213-014-3478-5. Epub 2014 Mar 1.PMID:24577515Protective effects of cannabidiol against hippocampal cell death and cognitive impairment induced by bilateral common carotid artery occlusion in mice.Schiavon AP, Soares LM, Bonato JM, Milani H, Guimarães FS, Weffort de Oliveira RM.
Neurotox Res. 2014 Nov;26(4):307-16. doi: 10.1007/s12640-014-9457-0. Epub 2014 Feb 15.PMID:24532152Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder.Liput DJ, Hammell DC, Stinchcomb AL, Nixon K.
Pharmacol Biochem Behav. 2013 Oct;111:120-7. doi: 10.1016/j.pbb.2013.08.013. Epub 2013 Sep 5. Erratum in: Pharmacol Biochem Behav. 2014 Nov;126:187-8. PMID:24012796
Free PMC ArticleNeuroprotection and reduction of glial reaction by cannabidiol treatment after sciatic nerve transection in neonatal rats.Perez M, Benitez SU, Cartarozzi LP, Del Bel E, Guimarães FS, Oliveira AL.
Eur J Neurosci. 2013 Nov;38(10):3424-34. doi: 10.1111/ejn.12341. Epub 2013 Aug 25.PMID:23981015Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors.Valdeolivas S, Satta V, Pertwee RG, Fernández-Ruiz J, Sagredo O.
ACS Chem Neurosci. 2012 May 16;3(5):400-6. doi: 10.1021/cn200114w. Epub 2012 Feb 9.PMID:22860209
Free PMC ArticleEffects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures.Moldzio R, Pacher T, Krewenka C, Kranner B, Novak J, Duvigneau JC, Rausch WD.
Phytomedicine. 2012 Jun 15;19(8-9):819-24. doi: 10.1016/j.phymed.2012.04.002. Epub 2012 May 7.PMID:22571976The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB(1)).Grabiec U, Koch M, Kallendrusch S, Kraft R, Hill K, Merkwitz C, Ghadban C, Lutz B, Straiker A, Dehghani F.
Neuropharmacology. 2012 Mar;62(4):1797-807. doi: 10.1016/j.neuropharm.2011.11.023. Epub 2011 Dec 13.PMID:22186081Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice.Kozela E, Lev N, Kaushansky N, Eilam R, Rimmerman N, Levy R, Ben-Nun A, Juknat A, Vogel Z.
Br J Pharmacol. 2011 Aug;163(7):1507-19. doi: 10.1111/j.1476-5381.2011.01379.x.PMID:21449980
Free PMC ArticleCannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease.Martín-Moreno AM, Reigada D, Ramírez BG, Mechoulam R, Innamorato N, Cuadrado A, de Ceballos ML.
Mol Pharmacol. 2011 Jun;79(6):964-73. doi: 10.1124/mol.111.071290. Epub 2011 Feb 24.PMID:21350020
Free PMC ArticleDiabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation.Liou GI.
World J Diabetes. 2010 Mar 15;1(1):12-8. doi: 10.4239/wjd.v1.i1.12.PMID:21537423
Free PMC ArticleThe neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors.Castillo A, Tolón MR, Fernández-Ruiz J, Romero J, Martinez-Orgado J.
Neurobiol Dis. 2010 Feb;37(2):434-40. doi: 10.1016/j.nbd.2009.10.023. Epub 2009 Nov 6.PMID:19900555Cannabinoids for the treatment of dementia.Krishnan S, Cairns R, Howard R.
Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007204. doi: 10.1002/14651858.CD007204.pub2. Review.PMID:19370677Cannabidiol: a promising drug for neurodegenerative disorders?Iuvone T, Esposito G, De Filippis D, Scuderi C, Steardo L.
CNS Neurosci Ther. 2009 Winter;15(1):65-75. doi: 10.1111/j.1755-5949.2008.00065.x. Review.PMID:19228180
Free PMC ArticleNonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity.Dirikoc S, Priola SA, Marella M, Zsürger N, Chabry J.
J Neurosci. 2007 Sep 5;27(36):9537-44.PMID:17804615
Free PMC ArticleEvaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties.García-Arencibia M, González S, de Lago E, Ramos JA, Mechoulam R, Fernández-Ruiz J.
Brain Res. 2007 Feb 23;1134(1):162-70. Epub 2006 Dec 28.PMID:17196181Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement.Esposito G, De Filippis D, Maiuri MC, De Stefano D, Carnuccio R, Iuvone T.
Neurosci Lett. 2006 May 15;399(1-2):91-5. Epub 2006 Feb 21.PMID:16490313Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity.Hamelink C, Hampson A, Wink DA, Eiden LE, Eskay RL.
J Pharmacol Exp Ther. 2005 Aug;314(2):780-8. Epub 2005 May 5.PMID:15878999
Free PMC ArticleCannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease.Lastres-Becker I, Molina-Holgado F, Ramos JA, Mechoulam R, Fernández-Ruiz J.
Neurobiol Dis. 2005 Jun-Jul;19(1-2):96-107.PMID:15837565